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The following original overview of the center is also available on NIH Reporter by putting Jolesz under the last name for PI.

Grant Number: 1U41RR019703-01A2



Abstract: We are requesting funds to establish a national Biomedical Resource Center in Image-guided Therapy (IGT) at the Brigham & Women's Hospital. The IGT Center proposed under this application will provide a unique, centralized infrastructure for clinical investigators, biomedical engineers, and basic scientists in promoting and advancing IGT methods and related clinical applications.

We will develop and make available new innovative technologies in five discrete TRD Core Projects:

  1. Computational Core
  2. Imaging Core
  3. MRI-guided Therapy Core
  4. Image-Guided Neurosurgery Core
  5. Focused Ultrasound Therapy Core

These key research initiatives represent the technical and clinical infrastructure of the Resource. They are anticipated to have significant effect on several future IGT methods and clinical applications; and will combine forces with 10 internal and 7 external, independently funded Collaborations that address various essential technical or clinical aspects of IGT. These collective scientific efforts include the development of image processing and display tools (3D Slicer, interactive and adaptive platforms, high performance computing); dynamic and adaptive MR imaging methods; novel therapy techniques (MRI-guided focused ultrasound); image-guided robotics; and several clinical applications from brain tumor surgery to prostate interventions. All IGT developments and applications will be tested either on site with our collaborators, or distributed directly as a service to the growing IGT community. Our overarching goal is to create a Center that is national in character reaching effectively across a broad range of constituencies through training in and dissemination of the novel technologies and methods under development in this Resource.

Project Start: 29-SEP-2005

Project End: 31-JUL-2010

The full Grant Application: IMAGE GUIDED THERAPY CENTER

Cores, Task Forces, and Collaborations

Detailed goals and activities of each of the areas of focus for the center is provided in the following sections.



  • This is where IRB information for the grant can be found.

Training, Dissemination, Service

External Advisory Board

Internal Steering Committee

Annual Calendar for U41

Other P41s

Collection of relevant information from other P41s.

Other IGT Grants

Relevant Grants from CRISP & REPORTER


Competitive Renewal

  • This is the scientific portion of the U41 renewal grant that was submitted to the NIH.
  • The competitive renewal planning steps are archived here.