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Confidentiality Note: This is a private wiki site only available to the Program Project leadership, Advisory Oversight Board members and NIH program management for the purpose of providing an open communications resource regarding information about and progress relating to our Program, NIH P01-CA67165. No information is to be copied, edited or disseminated from this site by anyone other than the Program Project investigators and staff authorized by the Program administration.

Grant Number: P01-CA67165 Final Progress Report for Closeout


This is where we start the brainstorming for the renewal.


The following overview of the P01 Grant application is also available from NIH's CRISP website: TBA. The previous award period's CRISP entry is on NIH Reporter.

Grant Number: P01-CA67165


Ferenc A. Jolesz M.D.


Abstract: The long-term objective of the application under consideration, a competing renewal of our Program Project in MR-guided Therapy, is to provide the scientific, medical, and technical infrastructure for the development of interventional and intraoperative MRI for the treatment of brain and prostate cancer. This Program Project combines several technological advances related to the use of high field MRI with an advanced imaging platform. In parallel, this proposal addresses issues related to limited access to the patient in the closed bore magnet. The goal is to move most of the procedures (open surgeries, thermal ablations) to the advanced 3Tesla imaging platform to achieve a faster and more flexible image acquisition which, in turn, will provide improved localization, targeting, monitoring and therapy control for those procedures that can be adapted to this new application environment. To this end, we will undertake the following research initiatives: Project 1: develop computational methods that account for anatomical changes during neurosurgical intervention and optimize the frequency of serial imaging ; Project 2: build an image-guided and controlled therapy delivery system for the non-invasive destruction of prostate cancer with MRI-controlled focused ultrasound; Project 3: provide image-control for manipulators and robotic devices that enhances the manual capacity of physicians and facilitates procedures in a closed bore magnet; Project 4: develop novel imaging platforms and methods for enhanced parallel MRI data acquisition applicable to image-guidance; and Project 5: create an integrated image-based system to allow MR-guided targeted interventions for the treatment of prostate cancer. These five projects will work synergistically to not only develop better imaging methods for defining the cancers, but will also work to facilitate the improved, targeted treatment of brain tumors and prostate cancer. This proposal combines several technological advances related to the use of high field MRI for the image guided treatment of brain and prostate cancer. The goal is to move most of the procedures (open surgeries, thermal ablations) to the advanced high field MRI imaging platform to achieve a faster and more flexible image acquisition which, in turn, will provide improved localization, targeting, monitoring and therapy control for those procedures that can be adapted to this new clinical application environment.

Project Start: 4/1/2007

Project End: 3/31/2012s

Progress Report

File:P01 Progress Draft.zip

File:P01CA067165 Progress Report 2010 2011 Final wout Budget.pdf

File:2009 2010 Jolesz P01 CA67165 11 Progress Report wout Budget.pdf UPS tracking: 1Z ORA 354 22 1001 1421 (1-800-742-5877, 1-800-PICK-UPS)

File:2008-2009 PO1CA67165 Progress Report wout Budget Pages.pdf


Program Honors

NIH CITATION OF P01-CA067165 AS Exemplar of NCI-Funded Translational Research

P01-CA067165 has been identified as an Exemplar of NCI-funded translational research. On May 22, 2008 Ferenc A. Jolesz M.D., PO.I. and Program Director of grant P01-CA067165, was invited to represent P01-CA067165 at the National Cancer Institute’s (NCI) Translational Science Meeting scheduled for November 7-9, 2008 at the Grand Hyatt in Washington, DC.

This meeting is designed to accelerate early translational cancer research and to encourage collaboration and enhancement of knowledge across NCI-funded research programs. It is the NCI's first step toward implementing the Translational Research Working Group's (TRWG) recommendations to develop a prioritization process and establish a new funding mechanism for early translational research. Contents of Letter from NCI to Ferenc A. Jolesz M.D. P.I. & Program Director

NCI TSC Workshop Poster of Ferenc A. Jolesz M.D. P.I. & Program Director, entitled "MR-Guided Thermal Therapies and Surgeries – Innovative Technologies to Ground-Breaking Clinical Practice"

NCI web page with goals and description of the translational science meeting.

Brief History of BWH MR-Guided Thermal Therapies and Surgeries Program - Two Decades of Achievements

MR-Guided Thermal Therapies and Surgeries - A Brief History of the Translation of Innovative Technologies to Ground-Breaking Clinical Practice

Ten Years of Tumor Ablations

BWH PikeNotes article of April 3, 2009, Ten Years of Thermal Ablations , commemorating ten years of clinical experience of the Division of MR and Interventional Radiology at BWH performing tumor ablations using MR-guided thermal therapies, a medical achievement originated by Ferenc Jolesz M.D. PI.

BWH Dept of Radiology in Top 5 NIH Funded Academic Radiology Departments

On April 8, 2008 Department of Radiology Chairman Steven Seltzer was informed by NIH that our BWH Department of Radiology ranks #5 in NIH-funded research among all academic Radiology departments receiving $18.8M in FY07 (4% increase over FY06), just $300k behind #4 Johns Hopkins and $2M ahead of #6 Stanford. MGH, our partner institution in Partners Healthcare, continues as #1.

Neurosurgery Reaches Milestone

September 8, 2006 BWH Bulletin cited Ferenc Jolesz MD and Peter McL Black MD for their leadership in the 1000th craniotomy occurring at the time of the 10th anniversary of MRI-guided craniotomies at BWH using the GE Signa/SP vertical configuration MRI scanner designed by Ferenc Jolesz MD in collaboration with GE Medical Systems. This is a significant event in Image-Guided Therapy at BWH. BWH Bulletin article

America's Best Hospitals: Top Ten Again

For the 17th consecutive year, BWH secured its place on the US News & World Report's Honor Roll of America's Best Hospitals July 2009 (article), ranking tenth from 4,861 surveyed. The distinction recognized a 'breadth of excellence' at BWH. The America's Best Hospitals guide ranked 174 medical centers nationwide in 16 specialities and placed only 21 centers on the 'best of the best' Honor Roll, including BWH.

BWH Named to Top Connected List Six Years Straight

BWH was named to Health Imaging & IT magazine's "Top 25 Connected Hospitals" in July 2009 for the sixth straight year, the only hospital in the U.S. to have made this prestigious list for this length of time. BWH was the only hospital in New England to make this list in 2009. This honor is given for making image-viewing available throughout the distributed campus and more than 40 operating rooms.Also, BWH clinicians perform electronic order entry more than 98% of the time. There are more than 5 million images viewed each month at BWH. (full article from BWH PikeNotes)

Projects and Cores

Detailed goals and activities of each of the Projects and Cores for the Program are provided in the following sections. Individual Project pages contain progress to date. Individual Core pages contain description of support of Projects to date.

Project 1 - Integrated Intraoperative Guidance for Neurosurgery

Project Research Leadership: Alexandra J Golby MD

Alexandra Golby M.D.

Project 2 - MR Guided Focused Ultrasound

Project Research Leadership: Nathan J McDannold PhD

Nathan McDannold Ph.D.

Project 3 - Image-Based Navigation for Interventional Robotic Devices

Project Research Leadership: Nobuhiko Hata PhD

Nobuhiko Hata P.D.

Project 4 - Enhanced Parallel MRI Data Acquisition

Project Research Leadership: Gary P Zientara PhD & Lawrence P Panych PhD

Gary P. Zientara Ph.D.
Lawrence P. Panych Ph.D.

Project 5 - MRI Guided Interventions in the Prostate

Project Research Leadership: Clare M Tempany MD

Clare Tempany M.D.

Clare Tempany

Core A - Biostatistical Validation

Biostatistical Consult Service of the Center for Clinical Investigation. Biostatistics support will be contracted on an as-needed basis to investigators from the Biostatistical Consult Service of the Center for Clinical Investigation at BWH. This service is part of the Biostatistics Core of the BWH Center for Clinical Investigation.

Core B - Administration

Core Leadership: Ferenc A Jolesz MD (P01 Director), Gary P Zientara PhD (Executive Director)

Presentations by P01 Leadership

February 15-19, 2010 MGH/BWH MRI 2010 Clinical Updates and Practical Applications.] Drs. Tempany and Jolesz

November 5-7, 2009 NCI Translation Science Meetin], Vienna, VA. Clare M. Tempany, Gabor Fichtinger, E. Clif Burdette "Standardized Network Communication for MRI-guided Robotic Prostate Interventions"

November 2009 Radiological Society of North America 2009 - Presentations by P01 leadership

October 26-30, 2009 MRI/CT Update Postgraduate Course BWH. Dr. Tempany and Dr. Golby

October 2009, 39th Annual Meeting of the Society for Neuroscience, Chicago Illinois, Lauren J. O’Donnell, Laura E. Rigolo, Isaiah Norton, Carl-Fredrik Westin, William M. Wells, and Alexandra J. Golby. Measurement of Quantitative spatial structure-function relationships using DTI and fMRI (in patients with structural lesions).

October 8-10 2009, COMSOL Conference 2009 Boston, MA G. Bonmassar and A. Golby, "Designing Polymer Thick Film Intracranial Electrodes for Use in Intra-Operative MRI Setting"

September 14, 2009 BRI Technology Innovation Program-CIMIT Fall Symposium. Dr. Tempany "Clinical Innovation in Image-guided Therapy"

September 2009, MICCAI 2009 Workshop on Diffusion Modelling. London, England Lauren J. O’Donnell, Laura E. Rigolo, Isaiah Norton, Carl-Fredrik Westin, and Alexandra J. Golby. Defining Spatial Relationships Between fMRI and DTI Fiber Tracts

August 25-27 2009 IBMISPS International Brain Mapping & Interoperative Surgical Planning Society Dr. Jolesz was an invited lecturer. "Operating Room of the Future".

July 16-19, 2009. 9th International Congress on Genitourinary Malignancies, Washington DC, Dr. Tempany, "Prostate Imaging"

July 11, 2009 Annual Meeting of the Japan Academy of Neurosonology, Osaka, Japan. Dr. Jolesz, "The Future of Intraoperative MRI".

June 25-27, 2009. Minimally Invasive Intervention for localized Prostate Cancer Course, NYU School of Medicine, Dr. Tempany

June 14, 2009 Intraoperative Imaging Society Meeting, Istanbul,Turkey, Dr. Jolesz "Future of Introperative MRI"

June 6-7, 2009 ISMRM Weekend Case-Based Clinical Education Program, New York, Dr. Tempany "Body MR"

June 1-4, 2009 Practical MR Imaging of the Abdomen and Pelvis, BWH. Dr. Tempany, "Prostate and MR Sequences_Pelvis"

May 26, 2009 CIMIT Forum Plan - "Living Laboratories" Across the Continuum of Care: Innovative Spaces and Virtual Places,Clare Tempany, "Advanced Procedure Room"

May 2009, 77th Annual Meeting of the American Association of Neurological Surgeons (AANS), San Diego, CA. Radmanesh A, Whalen S, Zamani AA, Jolesz FA, Golby AJ. "Single-Tensor versus Two-Tensor Method in Diffusion Tensor Tractography to Demonstrate the Hand and Face Motor Fibers for Surgical Planning."

May 2009. Alex Golby, Oral Presentation. Golby A, review course on brain tumor, 77th Annual Meeting of the American Association of Neurological Surgeons (ANNS), San Diego, CA.

March 23-24, 2009: Brain FUS Meeting, Washingon, DC. Nathan McDannold.

February 16-20, 2009 HMS/BWH's MRI 2009 Course Boston, Chaired by Drs. Tempany and Jolesz

April 3-7, 2009. Society for Thermal Medicine, Tucson, Arizona. Nathan McDannold, PhD co-chair, Symposium III: New Developments in MR-Guided High Intensity Focused Ultrasound, with Chris Diederich, PhD.

January 28, 2009. Radiological Sciences Lab, Stanford University, Nathan McDannold. "MRI-guided Focused Ultrasound for Ablation and Drug Delivery"

January 24-29, 2009, SPIE 2009 BiOS Biomedical Optics Symposium at which Nathan McDannold will present Pre-clinical evaluation of an MRI-guided transrectal focused ultrasound system for thermal ablation of prostate cancer in canines

November 2008 Radiological Society of North America 2008 - Presentations by P01 leadership

November 12, 2008. Annual Biomedical Research Symposium, University of Michigan, Ann Arbor, Ferenc Jolesz MD "Multimodality Image-Guided Therapy"

  1. October 22, 2008. Nobuhiko Hata, gave a seminar titled "Role of Image Processing, Navigation and Robots in MRI-guided Intervention," Bioimaging Sciences Division, Department of Radiology, Yale University School of Medicine, New Heaven, CT.
  2. October 17, 2008. Nobuhiko Hata presented a seminar titled "Role of Image Processing, Navigation and Robots in MRI-guided Intervention," Robarts Institute, University of Western Ontario, Ontario, Canada.

Oct 6-7, 2008. MR guided Focused Ultrasound Symposium, Washington, DC, USA. Presentations by Drs. McDannold and Jolesz

September 25-27, 2008. Awake Surgery and Cognitive Mapping. Verona, Italy. Alex Golby presented Coregistration and display of pre-and intra-operative multimodality brain mapping data for surgical decision-making

September 12, 2008, 7th Interventional MRI Symposium http://imri2008.com/, Baltimore MD. Real-Time MR Data Acquisition System for IGT in the AMIGO Suite, Gary P. Zientara, Renxin Chu, W.Scott Hoge, Bruno Madore, Junichi Tokuda, Haiying Liu, Nobuhiko Hata, Chang-Sheng Mei, Lawrence P. Panych.

September 10-13, 2008. 8th Meeting of the International Society on Therapeutic Ultrasound. Presentation by Nathan McDannold

August 12, 2008: NIDDK Technology in Urology and Nephrology Local Workshop. Cambridge, MA. Image Guided and Enabling Technologies in Genito-Urinary Disease. Presentation by Clare Tempany.

"May 19, 2008: Project 4 Leaders Gary P. Zientara Ph.D. nad Lawrence P. Panych Ph.D. are announced as recipients of Partners Healthcare Sustaining Research Excellence Awards."

May 3-9, 2008 ISMRM, Toronto CA, 16th Scientific Meeting and Exhibition. Presentations by P01 Leadership

"BWH Advances Nuclear Imaging by Installing Cyclotron and Starting Collaborations with Other Longwood Medical Area Clinical and Research Groups - BWH Bulletin March 21, 2008"

March 20, 2008, MR guided focused ultrasound featured at Society of Interventional Radiology, March 15-20, Washington, DC, Drug Delivery : HIFU ablation + enhanced drug delivery with focused US, Nathan McDonnold

December 3-4, 2007, 15th Annual Tumors of the Central Nervous System, Brain Tumor Management, Boston, MA. Drs. Alex Golby, Peter Black. Dr. Golby spoke on Brain Mapping in Glioma Management.

November 2007 Radiological Society of North America 2007 - Presentations by P01 leadership

Nov 6, 2007. Mathematical Methods for Medical Image Analysis Neculai Archip gave the invited talk Medical Image Analysis for Image Guided Therapy

Oct 10-13, 2007 Intl Conference on Glioma Research and Therapy Alex Golby and Peter Black spoke on glioma imaging and therapy.

September 27, 2007: Clare Tempany, M.D., gave a invited presentation on imaging approach for active surveillance at the PHEN 3rd Annual African American Prostate Cancer Disparity Summit.

August 2007: Clare Tempany, M.D., presented on the latest advances in diagnostic imaging at the BWH Ninth Annual Prostate Care Symposium where 300 people were in attendance.

ISMRM 2007 - Abstracts from P01 PIs and researchers

[ISMRM 2007 - Presentations by P01 leadership]

"BWH Builds Nuclear Medicine Facility" describes AMIGO cyclotron, article in BWH Medical Staff News May 2007

"BWH Radiology Named to Industry "Cream-of-Crop" List" BWH Radiology clinical service named 4th in nation by Medical Imaging magazine, article in BWH Medical Staff News May 2007

"Clare Tempany-Adfhal Named First Incumbent of the Ferenc Jolesz Distinguished Chair in Radiology Research - BWH Medical Staff News Dec 2007"

Annual Progress Report 2008-2009 (Submitted to NCI NIH for March 1, 2009)

Annual Progress Report 2007-2008 (Submitted to NCI NIH for March 1, 2008)

Contact Information for P01 Project PIs, Key Investigators, Administrative Staff, GE Staff, & NIH Program Management

Project PIs, Key Investigators, Administrative Staff, GE Staff, & NIH Program Management Contact Information

Budget Information - Billing to Projects

  • Contact Susan Cassidy-Zipkin at SZIPKIN@PARTNERS.ORG or 617-525-8734 (O)

How to Acknowledge P01 in Publications

  • "Support from NIH P01-CA67165 is gratefully acknowledged."

Administrative Meetings of Program, Project & Core Leadership

Meetings of Project and Core Leaders with Program Director

Meetings of Project and Core Leaders with Radiology Research Administration

Intra-Program Collaborations Between Projects and Cores

Ad Hoc Meetings & Joint Research Events between Projects and Cores

External Advisory Board

EAB meetings

EAB members

  1. (Project 1)
    Simon K. Warfield Ph.D.
    Simon K. Warfield Ph.D. Associate Professor of Radiology, Director of the Computational Radiology Laboratory, Dept of Radiology, Children's Hospital Boston (Expertise in medical image segmentation and post-processing) http://www.dfhcc.harvard.edu/membership/member-profile/member/9091/0/
  2. (Project 2) Victor Frenkel Ph.D., Head, Therapeutic Ultrasound Research Molecular Imaging Lab, Diagnostic Radiology Department, National Institutes of Health, Bethesda, MD
  3. (Project 3)
    Peter Kazanzides Ph.D.
    Peter Kazanzides Ph.D., Chief Systems and Robotics Engineer, Engineering Research Center for Computer Integrated Surgical Systems and Technology, Johns Hopkins University, Baltimore, MD http://www.cisst.org/~pkaz/
  4. (Project 4)
    Elfar Adalsteinsson Ph.D.
    Elfar Adalsteinsson Ph.D. Associate Professor of Electrical Engineering, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, and Associate Professor of Health Sciences and Technology Harvard-MIT Division of Health Sciences and Technology http://www.rle.mit.edu/rleonline/People/ElfarAdalsteinsson.html (Expertise in optimal imaging strategies and methods.)
  5. (Project 5)
    Gabor Fichtinger Ph.D.
    Gabor Fichtinger, Ph.D., Associate Professor, Computer Science, Mechanical and Materials and Materials Engineering; Electrical and Computer Engineering, and Surgery; Queen’s University, Kingston, Ontario, Canada. Adjunct Associate Professor of Computer Science, Mechanical Engineering and Radiology; Johns Hopkins University, Baltimore, MD. http://research.cs.queensu.ca/~gabor/

Internal Advisory Board

IAB meetings

IAB members

  1. Peter Black, MD: Chief of Neurosurgery and Clinical Collaborator in intraoperative brain surgery(http://www.brighamandwomens.org/researchsummaries/neurosurgery_black_peter.aspx)
  2. Anthony D’Amico, MD: Chief of Radiation Oncology and Clinical Collaborator in Prostate Therapy(http://www.brighamandwomens.org/mri/mrt.aspx)
  3. Harvey Cline, PhD: GE Corporate Research and Development, General Electric Company Collaborator in Focused Ultrasound Research
  4. W Eric Grimson, PhD: Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Collaborator in Computer Science and Robotics (http://www.csail.mit.edu/biographies/PI/bioprint.php?PeopleID=2008)

BWH Human Subjects Research Resources

BWH / BRI Cores & Facilities Resources

Distinction between the P01 Research & U41 NCIGT Research

Distinction between the P01 Research & U41 NCIGT Research

Mutual Benefits of P01 & U41 Research Collaborations

MRI Facilities Hardware & Software (Levels/Status/Current State)

Current Hardware & Software State of MRI Scanners

MRI-Compatible Equipment Vendors & Summary Websites

Program-Wide Relevant Web Links

Radiology-Related Web Search Engines

NIH CRISP Database Contents Re: Image-Guided Research

http://crisp.cit.nih.gov/crisp/crisp_query.generate_screen NIH's CRISP Database Search Engine - Locate NIH-funded projects and programs of interest

IGT Community Portal

Grant Writing Help

Grant Writing Help and Advice for eSubmission

Editorial Services

  • For assistance writing/editing text or PowerPoint slides associated with online pages, manuscripts, white papers, presentation materials, grant submissions, etc.
  • Please contact Kim Lawson, Editor, via email at: klawson1@partners.org or via cell phone at 617-543-2803. Feel free to leave a message on the voice mail with your name and number clearly stated, and I will return the call.

Graphics Resources

Free Poster-Making Facility - FREE POSTER PRODUCTION

  • Location: Harvard New Research Building on Avenue Louis Pasteur across from LMRC. Go in the door, up the stairs, straight ahead past the cafe and through some doors. There is a security guard there at the 2nd floor security station. The room with the poster printer is adjacent to the security station on the left.
  • What You Need to Take With You:
  1. Your poster MS Powerpoint (.ppt file) on a CD or floppy disk or Zip disk. NOTE: NO USB flash memory, NO internet connection. (The PC that supports the printer is quite old.)
  2. Jing’s additional suggestion: The CD ROM drive on the PC is quite old, so sometimes it could not read disks with bad quality. I suggest you to bring a laptop with a CD burner and extra CD disks to the printer room so that you could burn a new CD just in case the first one could not be read.
  3. Noby’s additional suggestion: The printer uses thin paper. You may wish to go to STAPLES and purchase some heavier poster paper yourself. Check out the Facility first to see what maximum paper size is allowed.
  • What to Do When You Get There: There are detail instructions on printer use are located beside the PC connected to the printer in that printer room. You just need to follow the instructions. It is not difficult to print.
  • Good Suggestion (from Larry): The best idea is just to take a walk over there and check it out well before using it.

(Thanks very much to: Jing Yuan, Noby Hata and Larry Panych for this valuable information.)

Partners Secure File Transfer Site

The address is https://transfer.research.partners.org

  • EASY WAY TO TRANSFER BIG GRANT FILES (up to several Gbytes) to Radiology Research Administration and others inside the Partners net. To become a new user you must be 'invited' by a current user - call me Gary Zientara x31647 or Jean Valk 617-5258737 or your Admin in Jean's office to 'invite' you to become a user. Then you can 'invite' others in your lab to join.
  • Once the external user signs up from the invite email, they will be able to send you files. The process looks exactly like sending an attachment with an email. In fact, an email notice is sent to the recipient, and a confirmation is sent back to you that the recipient has downloaded your file.
  • A quick start guide is available at the Research Computing web site at: http://www.partners.org/rescomputing/content/secureFiletransfer.asp

Steps to Invite a new user:

  1. First you have sign up and login to the File Transfer Service at https://transfer.research.partners.org
  2. After you login to the system click on the Send File tab
  3. The Invite link is located in the upper right corner
  4. Once you click in the invite link a small window will open and then enter the email of the person you want to invite
  5. Then click the invite button to send.