October 29, 2007: Jolesz Chair Establishment

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The Ferenc Jolesz, MD Distinguished Chair in Radiology Research

Monday, October 29, 2007 Brigham and Women’s Hospital

WELCOMING REMARKS Steven E. Seltzer, MD Chairman, Department of Radiology Brigham and Women’s Hospital

REMARKS Gary L. Gottlieb, MD, MBA President Brigham and Women’s Hospital

Mark Vachon President and CEO, Diagnostic Imaging GE Healthcare

Ferenc A. Jolesz, MD Vice Chair for Research, Department of Radiology Director, Division of Magnetic Resonance Imaging Brigham and Women’s Hospital

Clare Tempany-Afdhal, MD Director of Clinical MRI Jolesz Distinguished Chair in Radiology Research Department of Radiology Brigham and Women’s Hospital

CLOSING Steven E. Seltzer, MD

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Over the past 25 years, Dr. Ferenc Jolesz has made extraordinary and unique contributions to the Department of Radiology at Brigham and Women’s Hospital and research programs at Harvard Medical School.

Trained originally as a neurosurgeon in his native Hungary, Dr. Jolesz immigrated to the United States in the 1970’s and re-established his professional career in Boston. Following a residency in radiology at Brigham and Women’s Hospital he was among the first in his generation to realize the power of the “marriage” of imaging, technology and surgery to create a new field of image-guided therapy.

In partnership with professional and technical colleagues, Dr. Jolesz’s first extraordinary accomplishment was the conceptualization, building and sitting of an “open architecture design” MRI unit that would be located in an operating room. Dubbed MRT for magnetic resonance therapy, Dr. Jolesz led the academic-industrial partnership that created the first “double doughnut” design for an open bore MRI, which was installed at BWH in the 1990’s. Through continued partnerships with his colleagues, Dr. Jolesz developed the image processing, navigation and visualization tools resident in the BWH Surgical Planning Laboratory, which are used every day to guide such procedures as MR-guided brachytherapy for prostate cancer, MR-guidance for percutaneous ablation of tumors in their abdominal viscera, craniotomies and other neurosurgical procedures in MRT.

Not content with these achievements, Dr. Jolesz continued his collaboration with colleagues to develop technologies for tissue ablation and targeted drug delivery that could be utilized in a completely noninvasive way. The first clinical proof of these concepts was the design, implementation and FDA approval for a system that uses high energy focused ultrasound, coupled with MR guidance for the ablation of tumors.

Dr. Jolesz was appointed Vice Chair for Radiology Research at Brigham and Women’s Hospital in 1990. He took responsibility for the growth and development of the entire Brigham Radiology Research enterprise. Under the leadership of Dr. Jolesz, radiology research at BWH has grown, diversified and prospered, and through his energetic vision, more than a dozen major laboratories now operate within the department.

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Dr. Clare Tempany-Afdhal, a native of Dublin, Ireland, is a medical graduate of the Royal College of Surgeons in Ireland. She is a diagnostic radiologist, who completed her radiology residency at Loyola University of Chicago and received board certification in diagnostic radiology in 1988. She completed a MRI fellowship at Johns Hopkins in 1990 and joined the faculty at Johns Hopkins before moving to Boston. In 1991 she joined the Department of Radiology faculty member at Brigham and Women’s Hospital. She is currently the director of Clinical Focused Ultrasound, at BWH and a Professor of Radiology at Harvard Medical School.

Her major areas of research interest are MR imaging of the pelvis and image-guided therapy. She has had a long-standing interest in MR imaging of prostate cancer – diagnosis, staging, and treatment. Beginning at Hopkins, where in 1990 she led the NIH funded RDOG trial, in MR staging of prostate cancer. In 1996 she received a GE-AUR career development award and since that time she has devoted a significant portion of her efforts to imaging research. She now leads an active research group- the MR guided prostate interventions laboratory, which encompasses basic research in IGT and clinical programs. In this research the team is seeking to integrate the multi-modal image data sets into the MR operating room. This was first developed for the MRT system, where it was successfully used in the diagnosis and treatment of over 500 men with prostate cancer. This and new novel methods of treatment will be transported and re-defined for the new image guided operating room or AMIGO platform. These included MR guided robotics/ enabling technologies for the interventions and the very exciting new non-invasive MR guided Focused ultrasound. Dr Tempany led the MRgFUS clinical trials for uterine fibroids and will embark upon its introduction for prostate cancer.

She and Dr Jolesz have been friends and colleagues for over 15 years and now together co-lead the NIH funded, National Center for Image guided therapy- NCIGT.

(inside right panel)

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