Kathy Nightingale Visit 2013

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Monday, October 28th


Acoustic Radiation Force Impulse (ARFI) Ultrasonic Elasticity Imaging of Prostate

We are developing a 3D acoustic radiation force impulse (ARFI) ultrasonic elasticity prostate imaging system, with the goal of providing improved ultrasonic contrast for biopsy targeting, focal therapy guidance, fusion with MR images, and imaging feedback for temporal monitoring of disease progression. In an ongoing pilot study, we obtain ARFI, B-mode ultrasound (US), and MR images in subjects prior to radical prostatectomy, and correlate the imaging findings with whole mount histology data in order to determine what structures and regions of pathology are portrayed by this new imaging modality. Preoperative prostate MR images (T1, T2, and DCE and DWI techniques), and 3D ARFI and B-mode US images are obtained immediately preceding radical prostatectomy with a side fire (ER7B) endorectal array controlled by an external rotation stage and a modified Siemens SC2000 scanner. The excised specimens are fixed in formalin for 48 hours; sectioned and processed using whole mount techniques; and digitized. Images are segmented using ITKsnap and 3D slicer, and images are evaluated for co-localization of zonal anatomy and pathology in all modalities. In vivo ARFI images delineate anatomic zones of the prostate with higher contrast than the B-mode US images. Additionally, many cancers have been identified as asymmetrical stiffer regions in coronal and axial prostate imaging planes, which have shown concordance with histologic regions of cancer. In many patients, regions identified by radiologists as suspicious for PCa in the MR image volumes have demonstrated correlation with regions of increased stiffness in ARFI. Atrophy of prostate tissue can be a confounding factor for both ARFI and MR images in identifying regions of suspicion for cancer. The high contrast of some PCa lesions and the structural detail of the ARFI images appear promising for biopsy targeting and focal therapy guidance, as well as for MR image fusion techniques.

Funding Source: NIH R01 CA142824

Information About Speaker


Meeting Agenda

Brigham Invited Participants

  • Morning: all NCIGT core PIs, Kemal, Fiona, Andriy
  • Afternoon: Physics and Computation Scientists, anyone else who would like to contribute

Agenda for Day:

  • 10am-12pm: Hollenberg
    • 10am - Presentation by Kathy on Prostate Imaging Using ARFI, Discussion
    • 11:30am - Presentation of Prostate mpMRI and biopsy (Kemal)
  • 12pm - lunch
  • 1pm: relocate to 221 Longwood
  • 1-1:30pm FUS lab tour (Nathan)
  • 1:30-3:30pm BWMRC conference room, 221 Longwood
    • 1:30-3:15pm: brainstorming about potential collaborations (led by Ehud, Nathan)
    • 3:30pm: KM In cab for airport.