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Advanced CT-guided Biopsy for Genome-Targeted Therapy of Lung Cancer (PI: Hatabu)


The four following NCIGT related proposals have been funded by CIMIT for the upcoming year:

  1. Intraoperative Sterotactic meloecular Imaging of Tumor Boundaries by Mass Spectrometry. Nathalie Agar PI.
  2. Diagnosis of diffuse axonal injury using robust tract-based quantification of diffusion tensor imaging. Lauren O'Donnell PI.
  3. Advanced Ureteroscope Navigation system for Calculi removal. Diane Sacco (MGH) PI.
  4. Robot-assisted laparoscopic prastatectomy guided by patient-specific models. Junichi Tokuda PI.


The proposal for CIMIT IGT Program Leadership is available here.

AMIGO Support Multimodality Image-Guided Therapy (PI Ellis, Co-I Hata)


The Advanced Multimodality Image-Guided Operating suite (AMIGO suite) will provide an exceptional and unique facility for developing and deploying various intraoperative imaging methods for guiding novel pioneering interventional and surgical procedures. The proposed research will provide the essential infrastructure for integrating up to seven independent sources of intraoperative medical images: MRI, PET, CT, fluoroscopy, ultrasound, optical imaging, endoscopy, and stereoscopic microscopy. No commercial or research software is currently capable of such multimodal integration because of the significant technical challenges. For example, software for handling 3D medical images, such as MRI and CT, is well understood but software for handling 2D projective fluoroscopic images or 2D reflective ultrasound images requires complex calibration and tracking.

In the first of three stages of research, software will be developed to support multiple 3D tracking technologies (optical and electromagnetic technologies in particular). In the second stage, the software will be outfitted with the capability of calibrating tracked fluoroscopic images and ultrasound images. Finally, the software will be modified to permit intraoperative fusion of these imaging modalities.

This software will allow rapid translational research in collaboration with clinical colleagues in neurosurgery, oncologic surgery, cardiovascular surgery, and orthopedic surgery as well as with interventional radiologists. We can subsequently develop a significant number of innovative procedures, patent them, and finally commercialize the new surgical techniques.


  • E Samset, A Hans, J von Spiczak, S DiMaio, R Ellis, N Hata, F Jolesz. The SIGN: A dynamic and extensible software framework for Image-Guided Therapy, Insight-Journal.
  • E Samset, D Kacher, P Aksit, GH Reynolds, LM Epstein, FA Jolesz. "ECG Triggered MRI-Guided Navigation for Cardiac Interventions", ISMRM 06 (Seattle, WA) p1400
  • J von Spiczak, E Samset, DF Kacher, CR Burghart, FA Jolesz, SP DiMaio. "A Voice Command Interface for Real-time Interventional MR Imaging", ISMRM 06 (Seattle, WA). p 1447



CIMIT has announced its annual Request for Applications for its Science Grants and Clinical Systems Innovation Grants, which provide support to research teams focusing on early stage medical devices, procedures, diagnosis and procedural systems that will result in better patient care.

Applicants for both categories should submit a short pre-proposal, due February 9. Those whose pre-proposals are accepted will develop a full proposal by March 16. A review board will make its decisions by May 4. More information about applying.

CIMIT Science Grants are offered in four science categories: small (up to $40,000 direct cost, for one year); medium (up to $100,000, one year); two-year large (up to $250,000 direct cost per year, for two years); and two-year medium, (up to $100,000 direct cost per year, for two years).

CIMIT encourages applications by innovators who reach across member institutions, and whose novel ideas might create technologies that can benefit several medical disciplines. CIMIT is particularly interested in new approaches for managing combat trauma, including hemorrhage control, traumatic brain injury and extending the “golden hour” (the moments between injury and arrival at a medical center). It currently funds projects in diagnostics, image-guided therapies, tissue engineering, neurotechnology, minimally invasive surgery, sepsis detection, trauma and casualty care, simulation, cardiovascular disease, global health and traumatic brain injury. CIMIT does not support drug development, information-technology projects or clinical trials.

CIMIT Clinical Systems Innovation grants support initiatives to advance systems that help improve clinical care in healthcare settings. These grants, up to $75,000 direct, help clinicians and institutions craft novel approaches to implementing enhancements such as design of a new facility or development of a better process through incorporation of innovative technology. Last year CIMIT announced distribution of close to $5 million in grants.